Science Translational Medicine featured recent research by
Elizabeth Nance and
Graeme Woodworth on the cover of their Aug 29th issue. Their work shows that much larger than previously expected nanoparticles can penetrate within normal human and rodent brain tissue, but only if densely coated with a bio-inert, hydrophilic polymer, poly(ethylene-glycol) or PEG. Achieving penetration in the brain with larger particles allows for greater flexibility in designing particles that have more uniform, longer-lasting, and effective delivery of drugs within the brain.
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