Publications 2007-2010

  1. Tang BC, Fu J, Watkins DN, Hanes J, (2010) Enhanced efficacy of local etoposide delivery by poly(ether-anhydride) particles against small cell lung cancer in vivo, Biomaterials, 31: 339-344.
  2. Lai SK, Wang Y-Y, Hida K, Cone R, Hanes J, (2010) Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses, Proc Natl Acad Sci USA, 107: 598–603.
  3. Hida K, DiPasquale G, Chiorini J, Hanes J, Ostermeier M, (2010) Sites in the AAV5 capsid tolerant to deletions and tandem duplications, Archives of Biochemistry and Biophysics, 496: 1-8.
  4. Aich U, Meledeo MA, Sampathkumar S-G, Fu J, Jones MB, Weier C, Chung SY, Tang B, Yang M, Hanes J, Yarema KJ, (2010) Development of delivery methods for carbohydrate-based drugs: Controlled release of biologically-active short chain fatty acid-hexosamine analogs, Glycoconj. J., 27: 445-459.
  5. Whaley KJ, Hanes J, Shattock R, Cone RA, Friend DR (2010) Novel Approaches to Vaginal Delivery and Safety of Microbicides: Biopharmaceuticals Nanoparticles, and Vaccines, Antiviral Res, Dec.:S55-66.
  6. Lai SK, O’Hanlon ED, Harrold S, Man ST, Wang YY, Cone R, Hanes J. (2007) Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus.  Proc Natl Acad Sci USA, 104 (5): 1482-1487. “Editor’s Choice”, Drug Discovery Today, News pieces on this paper appeared in JAMA, Nature Nanotechnology, NCI Nanotechnology Alliance Website, ABC News, and other respected places.
  7. Lai SK, Hida K, Man ST, Chen C, Machamer C, Schroer TA, Hanes J. (2007) Privileged delivery of polymer nanoparticles to the perinuclear region of live cells via a non-clathrin, non-degradative pathway. Biomaterials, 28: 2876-2884. “Editor’s Choice”, Drug Discovery Today,
  8. Hida K, Hanes J, Ostermeier M (2007) Directed Evolution for Drug and Nucleic Acid Delivery, Adv Drug Del Rev, 59: 1562-1578.
  9. Suk JS, Suh J, Lai SK, Hanes J, (2007) Quantifying the intracellular transport of viral and nonviral gene vectors in primary neurons, Experimental Biology and Medicine, 232:461-469. Society for Experimental Biology and Medicine Best Paper for 2007 in experimental biology/basic research
  10. Suh J, Choy K-L, Lai SK, Suk JS, Tang B, Prabhu S, Hanes J, (2007) PEGylation of nanoparticles improves their cytoplasmic transport, Int. J. Nanomed., 2(4):1-7.
  11. S.K. Lai, K. Hida, C. Chen, J. Hanes (2008) Characterization of the intracellular dynamics of a Non-Clathrin and Non-Caveolae Pathway Using High Resolution Confocal Particle Tracking, J. Controlled Release, 125: 107-111. 
  12. Deosarkar SP, Malgor R, Fu J, Kohn LD, Hanes J, Goetz DJ (2008) Polymeric Particles Conjugated with a Ligand to VCAM-1 Exhibit Selective, Avid and Focal Adhesion to Sites of Atherosclerosis, Biotechnol Bioeng, 101(2):400-407.
  13. Wang YY, Lai SK, Suk JS, Pace A, Cone R, Hanes J, (2008) Addressing the PEG Muco-adhesivity paradox to engineer nanoparticles that “slip” through the human mucus barrier, Angew. Chem. Int. Ed., 47 (50): 9726-9729.  [Impact 12.73]Commentary on this article: Cu Y and Saltzman WM (2009) Stealth Particles Give Mucus the Slip, Nature Materials, 8: 11-13.
  14. Lai SK, Wang YY, Hanes J. (2009) Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues, Adv Drug Del Rev, 61:158-71.
  15. Lai SK, Wang YY, Wirtz D, Hanes J. (2009) Micro- and macro-rheology of mucus, Adv Drug Del Rev, 61:86-100
  16. Hanes J and Demeester J. (2009) Drug and Gene Delivery to Mucosal Tissues: The Mucus Barrier, Adv Drug Del Rev, 61: 73-74.
  17. Lai SK, Wang Y-Y, Cone R, Wirtz D, Hanes J, (2009) Altering mucus rheology to “solidify” human mucus at the nanoscale, PLoS ONE, 4(1): e4294. doi:10.1371/journal.pone.0004294.
  18. Suk JS, Lai SK, Wang Y-Y, Ensign LM, Zeitlin PL, Boyle MP, Hanes J, (2009) The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles, Biomaterials, 30: 2591-2597.
  19. Lai SK, Hida K, Shukair S, Wang Y-Y, Cone R, Hope TJ, Hanes J, (2009) Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus, J. Virol., 83: 11196-111200.
  20. Tang BC, Dawson M, Lai SK, Wang Y-Y, Suk JS, Yang M, Zeitlin P, Boyle MP, Fu J, Hanes J, (2009) Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier, Proc Natl Acad Sci USA, 106: 19268–19273.