Publications 2000-2003

  1. DiMeco, F., Rhines, L. D., Hanes, J., Tyler, B. M., Brat, D., Torchiana, E., Guarnieri, M., Colombo, M. P., Pardoll, D. M., Finocchiaro, G., Brem, H., Olivi, A. (2000) Paracrine delivery of IL-12 against intracranial 9L gliosarcoma in rats, Journal of Neurosurgery. 92: 419-427.
  2. Ewend, M. G., Thompson, R. C., Anderson, R., Sills, A. K., Staveley-O’Carroll, K., Tyler, B. M., Hanes, J., Brat, D., Thomas, M., Jaffee, E. M., Pardoll, D. M., and Brem, H. (2000) Intracranial paracrine interleukin-2 therapy stimulates prolonged antitumor immunity that extends outside the central nervous system, Journal of Immunotherapy. 23: 438-448.
  3. Hanes J, Sills AK, Zhao Z, Suh KW, Tyler BM, DiMeco F, Brat DJ, Choti MC, Leong KW, Pardoll DM, Brem H (2001) Controlled local delivery of interleukin-2 by biodegradable polymers protects animals from experimental brain tumors and liver tumors.  Pharm. Res. 18:899-906.
  4. Fu J, Fiegel J, Krauland E, Hanes J (2002) New polymeric carriers for controlled drug delivery following inhalation or injection, Biomaterials, 23: 4425-4433.
  5. Ehrhardt C, Fiegel J, Fuchs S, Abu-Dahab R, Schäfer UF, Hanes J, Lehr C-M (2002) Drug absorption by the respiratory mucosa: Cell culture models and particulate drug carriers, J. Aerosol Med., 15:131-140.
  6. Ehrhardt C, Kneuer C., Fiegel J, Hanes J, Schäfer UF, Kim K.J., Lehr C-M (2002) Influence of apical fluid volume on the development of functional cellular junctions in the human epithelial cell line 16HBE14o-: Implications for its use as an in vitro model for bronchial drug absorption studies, Cell & Tissue Res., 308: 391-400.
  7. Li H, Yuan Z, Ng TY, Lee HP, Lam KY, Wang QX, Wu S, Fu J, Hanes J (2003) Constitutive model development and micro-structural topology optimization for Nafion hydrogel membranes with ionic clustering, J Biomater Sci-Polymer E, 14:1181-1196.
  8. Rhines, L.D., P. Sampath, F. Dimeco, H.C. Lawson, B.M. Tyler, Y. Har-el, J. Hanes, A. Olivi, D.M. Pardoll, H. Brem. (2003) Local immunotherapy with interleukin-2 delivered from biodegradable polymer microspheres combined with interstitial chemotherapy: A novel treatment for experimental malignant glioma. Neurosurg, 52:872-880.
  9. Fiegel J, Ehrhardt C, Schäfer U, Lehr C-M, Hanes J (2003) Large Porous Particle Impingement on Lung Epithelial Cell Monolayers: Toward Improved Particle Characterization in the Lung, Pharm. Res., 20(5):788-796.
  10. Dawson M., Wirtz D., and Hanes J. (2003) Enhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transport, J. Biol. Chem., 278:50393-50401.
  11. Sakhalkar HS, Dalal MK, Salem AK, Ansari R, Fu J, Kiani MF, Kurjiaka DT, Hanes J, Shakesheff KM, Goetz DJ (2003) Leukocyte inspired biodegradable particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo, Proc Natl Acad Sci USA, 100:15895-15900.
  12. Suh J, Wirtz D., Hanes J (2003) Efficient Active Transport of Gene Nanocarriers to the Cell Nucleus, Proc Natl Acad Sci USA, 100: 3878-3882.