Technologies
Nanomedicine for Eye Injections
Topical application of eye drops is the most common way to deliver drugs to the eye to treat eye diseases. However, turnover of the tear …
Brain-penetrating Particles
In all tissues, including the brain, there is a dense matrix of structural proteins referred to as the extracellular space (ECS). In order to spread …
Mucus-penetrating Particles
All exposed entry points to the body (e.g. the airways, gastrointestinal tract, female reproductive tract, eyes) are coated with mucus. Mucus protects our epithelial surfaces …
Non-Viral Gene Vectors
Localized gene therapy is an attractive strategy to treat a variety of life-threatening diseases, spanning genetic disorders, infectious diseases and cancers. However, this approach has …
Commercialization
The mucus-penetrating particle technology has been commercialized by two companies, Kala Pharmaceuticals and Graybug, both founded by Dr. Justin Hanes, Director of the Center for …
Technologies
Nanotechnology is a powerful tool used for therapeutics and diagnostics to better understand, prevent, treat, and cure many diseases afflicting people today. We have developed …
Disease Targeting
Selected Publications
- Chan KW, Liu G, Song X, Kim H, Yu T, Arifin DR, Gilad AA, Hanes J, Walczak P, van Zijl PC, Bulte JW,
Gene Vectors
Localized gene therapy is an attractive strategy to treat a variety of life-threatening diseases, spanning genetic disorders, infectious diseases and cancers. However, this approach has …
Dendrimers
Dendrimers are tree-like nanostructured polymers, synthesized with a well-defined size. Even though there are a wide range of dendrimers with differing building blocks, PAMAM dendrimers …
Nanoparticles
Nanoparticles are spherical structures that can be made with numerous fabrication techniques. Nanoparticles can be made spanning a wide range of diameters, typically ranging from …
