Therapeutic options for central nervous system (CNS) disorders are limited for many patients. Therapeutic delivery to the brain faces many barriers to achieving sufficient drug concentrations at the diseased site while minimizing side effects and toxicity. Therapeutic platforms must overcome the blood-brain barrier (BBB), then penetrate into the tissue to reach the diseased cells often associated with many CNS diseases. Nanotechnology has emerged as an exciting and promising new means of treating neurological disease, with the potential to fundamentally change the way we approach CNS-targeted therapeutics. Nanotechnologies can be engineered to cross the BBB, diffuse within the brain tissue, target specific cell or signaling systems, and act as vehicles for delivering therapeutics. The wide variety of available nanotechnologies allows the selection of a nanoscale material with the characteristics best suited to an individual CNS disorder. We have developed both polymeric nanoparticles and dendrimer-based nanoparticle platforms that have both shown promise for application in CNS diseases.
Disease Focus Areas
- Brain Cancer
- Cerebral Palsy (CP)
- Fetal brain injury
- Traumatic brain injury (TBI)
- Autism spectrum disorder (ASD)
- Multiple sclerosis (MS)
- Parkinson’s disease
- Alzheimer’s disease
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